Endocrine Abstracts

Objectives: Orbital radiotherapy (OR) is the most commonly used second-line treatment for the severe forms of Graves’ orbitopathy (GO). The aim of our study was to assess the changes in the therapeutic response, ocular manifestations of GO and quality of life (QoL) during the first year after OR.Methods: The study involved 26 consecutive patients with active moderate-to-severe GO indicated for OR, 18 females, mean age 57±12.5. At baseline all pat...

Introduction: Thyroid nodules can be detected by ultrasound (US) in 20–30% of unselected populations. Various non-surgical techniques such as laser and radiofrequency ablation have been developed to reduce thyroid nodule size. High-intensity focused ultrasound (HIFU) ablation is a new, non-invasive method that has been shown recently. The aim of our study was to assess the long-term efficacy and safety of US-guided HIFU treatment of benign solid thyroid nodules.<p cla...

IntroductionIn primary hyperparathyroidism (PHPT) the chronic overproduction of parathormone (PTH) is mostly due to a solitary adenoma.AimThe aim of our study was to examine the relationship between calcium-phosphate metabolism and the volume of the parathyroid adenoma (PTA) in patients with PHPT.Material and methodsThe study included 195 patients with biochemical...

IntroductionThyrotropin-receptor antibodies (TRAb) play a key role in the pathogenesis of Graves’ disease (GD) and Graves’ orbitopathy (GO) and are important for the diagnosis of both diseases. Elevated levels of immunoglobulin E (IgE) and antinuclear antibodies (ANA) were also found in GD patients. Smoking is a risk factor for GD and GO development and GO progression. We aimed to assess the associations between TRAb, IgE and ANA, and the prese...

The nodular goiter is the most prevalent thyroid disorder. Its prevalence increases with age and reaches over 70%. The aim of the study was to compare the nodule prevalence in two population-based studies, carried in Bulgaria in 2006 and 2012.Material and methods: Two thousand four hundred and two subjects (1347 female and 1053 male, age range 20–94 years) were included in 2006 and 2022 (1073 female and 949 male, 20–88 years) in 2012. All subje...

The aim of the study was to investigate the relationship among the indices of insulin resistance (IR), the lipid parameters and thyroid function in euthyroid adults.Material and methods: Two hundred and sixteen euthyroid adults, mean age 57.08±13.81 years (112 female and 104 male) were included. Serum lipirds, Immunoreactive insulin, glucose, TSH, waist circumference (WC), body height and weight were measured. HOMAi and BMI were calculated.<p cl...

AimTo assess the relative expression of tissue inhibitor of metalloproteinase-1 gene (TIMP1) and chitinase-3-like protein 1 gene (CHI3L1) in fine-needle aspiration biopsy (FNAB) washouts and the serum levels of their protein products (TIMP-1 and chitinase-3-like protein 1 also known as YKL-40) in patients with histologically confirmed papillary thyroid cancer (PTC) and with benign nodules. Further, we evaluated the correlation between the gene expression...

Objectives: To evaluate the quality of life (QoL) in patients with differentiated thyroid cancer (DTC) by a validated thyroid-specific questionnaire and to identify factors with significant impact on the QoL.Methods: Two hundred DTC patients, treated in one tertiary center, were recruited in the study. One year after the thyroid surgery, they completed the QoL Cancer Survivor Instrument – Thyroid version questionnaire. The questionnaire assessed the...